Characterization of Vitamin B12 Supplementation and Correlation with Clinical Outcomes in a Large Longitudinal Study of Early Parkinson's Disease

OBJECTIVE: In Parkinson's disease (PD), vitamin B12 levels are lower, and comorbid B12 deficiency has been associated with the development of neuropathy and early gait instability. Because little is known about B12 supplement use in PD, we sought to evaluate its use in a large PD cohort and, as an exploratory analysis, to determine whether baseline characteristics or disease progression differed according to B12 supplementation. METHODS: We utilized data collected as part of the National Institutes of Health Exploratory Trials in PD (NET-PD) Long-term Study (LS-1), a longitudinal study of 1,741 participants. We stratified subjects into 4 groups according to daily supplement use: no B12, multivitamin (MVI) containing < 100 μg B12, B12 ≥ 100 μg, and MVI + B12 ≥ 100 μg. Clinical outcomes were assessed at 3 years for each group using the Unified Parkinson's Disease Rating Scale (UPDRS), its subscores, and selected individual questions. RESULTS: Of the 1,147 participants who completed the 3-year visit, 41% took an MVI, 2% took B12, 3% took MVI + B12, and 54% reported taking no supplements. At 3 years, no significant differences in clinical outcomes were observed. However, there was a trend toward lower hazard ratios for developing sensory symptoms (UPDRS Item 17) in the MVI (p = 0.08) and B12 + MVI (p = 0.08) groups compared to that in the no supplement group. CONCLUSION: These results show that supplementation with vitamin B12 ≥ 100 μg is uncommon in early PD. The finding of a trend toward a lower hazard ratio for the development of sensory symptoms in those taking an MVI or B12 + MVI warrants further study.

Research and Design of Hypertensive Patients Health Management App Which Aims at Medication Compliance / 医学信息学杂志

The paper analyzes the cause for poor medication compliance of hypertensive patients,indicates the necessity of development of hypertensive health management APP,designs three core functions of the APP including health science popularization,medication reminding and blood pressure monitoring,promotes the improvement of medication compliance of patients,and improves the use intensity of users of the APP through the internal incentive measures that combining health belief and effect monitoring and the external incentive measures that focus on the reward system.

Study on influence of self-harmony in visiting first grade female college students on admission adaptation and mental health / 重庆医学

Objective To investigate the influence of self-harmony in visiting first grade female college students on admission adaptability and mental health to provide the theoretical and practical basis for preventing the mental problems and college mental health education work.Methods A total of 354 first grade female college students making the appointment for psychological consultation were selected as the research subjects and measured with the Self Consistency and Congruence Scale(SCCS),Symptom Checklist 90 (SCL-90) and Chinese College Student Adaptation Scale(CCSAS).Results The visiting first grade female college students had the psychological problems such as obvious social anxiety and accompanying with anxiety,depression and other the negative emotions,and unreasonable expectations of self-experience,starchiness and rigidity of self-harmony existed.The various factors of self-harmony and total score in the first grade female college students had different degrees of significant correlation with the various factors of admission adaptability and mental health(P<0.05);the disharmony between self and experience had a significantly positive predictive effect on the visiting first grade female college students′ mental health(P<0.05),but which had a significantly negative predictive effect on the admission adaptation(P<0.05).The admission adaptation had an incomplete mediating effect between self experience disharmony and mental health.Conclusion Self-harmony promotion contributes to improve female college students′ admission adaptability and mental health level.